ABSTRACT
Electrocardiographic (ECG) changes have been investigated in the condition of coronavirus disease (COVID-19) indicating that COVID-19 infection exacerbates arrhythmias and triggers conduction abnormalities. However, the specific type of ECG abnormalities in COVID-19 and their impact on mortality fail to have been fully elucidated. The present retrospective, tertiary care hospital-based cross-sectional study was conducted by reviewing the medical records of all patients diagnosed with COVID-19 infection who were admitted to Booali Sina Hospital in Qazvin, Iran from March to July 2020. Demographic information, length of hospital stay, treatment outcome, and electrocardiographic information (heart rate, QTc interval, arrhythmias, and blocks) were extracted from the medical records of the patients. Finally, a total of 231 patients were enrolled in the study. Atrial fibrillation was a common arrhythmia, and the left anterior fascicular block was a common cardiac conduction defect other than sinus arrhythmia. The deceased patients were significantly older than the recovered ones (71 ± 14 vs. 57 ± 16 years, p < 0.001). Longer hospital stay (p = 0.036), non-sinus rhythm (p < 0.001), bundle and node blocks (p = 0.002), ST-T waves changes (p = 0.003), and Tachycardia (p = 0.024) were significantly prevalent in the deceased group. In baseline ECGs, no significant difference was observed in terms of the absolute size of QT;however, a prolonged QTc in the deceased was about twice of the recovered patients (using Bazett, Sagie, and Fridericia’s formula). Serial ECGs are recommended to be taken from all hospitalized patients with COVID-19 due to increased in-hospital mortality in patients with prolonged QTc interval, non-sinus rhythms, ST-T changes, tachycardia, and bundle, and node blocks. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
ABSTRACT
SUMMARY. The sanitizers and disinfectants have become widely used due to the COVID-19 global health crisis. However, as much as these household products keep us clean and prevent transmission of the virus, excessive use of these can be harmful. Recently, many kinds of disinfectants have been used with very in-tensive usage of the right ones, as well as the hands wearing duration, too many people developed redness of the skin some have sustained injuries with the incidence of red skin spots in addition to scratching and eyes irritation, arising question, why in which required an explanation. This article aims to demonstrate that excessive use of antiseptics and disinfectants along with the length of time in contact leading to skin allergies. Shows a significant skin irritation, whereas the skin is the first physical defense barrier against many kinds of pathogens and one of the components of the immune system against microorganisms. RESUMEN. Los sanitizantes y desinfectantes se han vuelto ampliamente utilizados debido a la crisis de salud global del COVID-19. Sin embargo, por mucho que estos productos domésticos nos mantengan limpios y eviten la transmisión del virus, el uso excesivo de estos puede ser perjudicial. Recientemente, se han utilizado muchos tipos de desinfectantes con un uso muy intensivo de los correctos, así como la duración del uso de las manos, de-masiadas personas desarrollaron enrojecimiento de la piel, algunas han sufrido lesiones con la incidencia de man-chas rojas en la piel además de rascarse e irritación de los ojos, pregunta que surge, que requiere una explicación. Este artículo tiene como objetivo demostrar que el uso excesivo de antisépticos y desinfectantes junto con el tiempo de contacto conduce a alergias cutáneas. Muestra una irritación cutánea significativa, mientras que la piel es la primera barrera de defensa física contra muchos tipos de patógenos y uno de los componentes del sistema inmunológico contra los microorganismos.
ABSTRACT
Background: There is controversy about the efficacy of 5-alpha-reductase inhibitors in COVID-19 patients. Some assumed that finasteride might be a risk factor for deterioration and others proposed it as a possible adjunct treatment for moderate to severe COVID-19 infection in the elderly. Methods: We performed a randomized controlled clinical trial (registration ID IRCT20200505047318N1) on 80 hospitalized male patients aged >50 years diagnosed with COVID-19 pneumonia in a tertiary hospital in Qazvin (Iran) from April to July 2020. The patients were randomized into one of the 2 treatment groups using simple randomization. Treatment group patients underwent routine drug therapy and 5 mg finasteride once daily for 7 days. The primary endpoint was mortality rate and length of hospital stay (LOS), and secondary endpoints were peripheral capillary oxygen saturation, respiratory rate, and inflammatory markers changes. The study protocol was approved by the medical ethics committee of Qazvin University of Medical Sciences (registration ID IR.QUMS.REC.1399.080). Data were analyzed by statistical tests and SPSS version 25. Also, p<0.05 was considered to be statistically significant. Results: We found a significant difference on O2saturation among the 2 study groups on fifth day compared with the admission time (p= 0.018). The results did not show significant differences in mortality rate (2.5% vs 10%;p= 0.166) and LOS (p= 0.866) between patients in the finasteride and the control group. Conclusion: A short course of finasteride administration partially improves O2 saturation but does not influence other outcomes in hospitalized male patients aged >50 years with COVID-19 pneumonia. Further research in a large scale with longer follow-up is required to help clarify the role of finasteride in this setting. Copyright© Iran University of Medical Science
ABSTRACT
Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical consequences.